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KMID : 0363020070370040755
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Journal of Korean Academy of Periodontology
2007 Volume.37 No. 4 p.755 ~ p.766
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The Influence of Diabetes on of PGE2, MMP-14 and TIMP Expressions in Human Chronic Periodontitis
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Kim Seon-Woo
Park Jin-Woo
Suh Jo-Young
Lee Jae-Mok
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Abstract
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Purpose: The purposes of this study were to compare and quantify the expression of , MMP-14 and TIMP-1 in the gingival tissues of patients with type 2 diabetes mellitus and healthy adults of chronic periodontitis with alveolar bone resorption.
Material and methods: Gingival tissue samples were obtained during periodontal surgery or tooth extraction. According to the patient’s systemic condition & clinical criteria of gingiva, each gingival sample was devided into three groups. Group 1 (n=8) is clinically healthy gingiva without bleeding and no evidence of bone resorption or periodontal pockets, obtained from systemically healthy 8 patients. Group 2 (n=8) is inflammed gingiva from patients of chronic periodontitis with alveolar bone resorption. Group 3(n=8) is inflammed gingiva from patients of chronic periodontitis with alveolar bone resorption associated with type 2 diabetes. Tissue samples were prepared and analyzed by Western blotting. The quantification of MMP-14 and TIMP-1 were performed using a densitometer and statistically analyzed by one-way ANOVA followed by Tukey test.
Results: The expressions of MMP-14 and TIMP-1 were showed increasing tendency in group 2 & 3 compared to group 1. The expressions of , MMP-14 were showed increasing tendency in group 3 compared to group 1 and group 2. According to MMP-14 levels were increasing, showed increasing tendency in group 3, and although , MMP-14 levels were increasing, TIMP-1 levels were similar expressed comparing to group 2.
Conclusion: In conclusion, this study demonstrated that the expression levels of MMP-14 and TIMP-1 had increasing tendency in inflammed tissue. It can be assumed that and MMP-14 may be partly involved in alveolar bone resorptive process and the progression of periodontal inflammation associated to type 2 DM.
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KEYWORD
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PGE2, MMP-14, TIMP-1, DM
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